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Article

What cost mitochondria? The maintenance of functional mitochondrial DNA within and across generations.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 5 Jul 2014

Aanen Duur K, Spelbrink Johannes N, Beekman Madeleine

Abstract excerpt

The peculiar biology of mitochondrial DNA (mtDNA) potentially has detrimental consequences for organismal health and lifespan. Typically, eukaryotic cells contain multiple mitochondria, each with multiple mtDNA genomes. The high copy number of mtDNA implies that selection on mtDNA functionality is relaxed. Furthermore, because mtDNA replication is not strictly regulated, within-cell selection may favour mtDNA...

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Identifiers

PMID: 24864309
DOI: 10.1098/rstb.2013.0438
PMCID: PMC4032515

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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