Evolutionary defined role of the mitochondrial DNA in fertility, disease and ageing.

doi:10.1093/humupd/dmv024

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Evolutionary defined role of the mitochondrial DNA in fertility, disease and ageing.

Human reproduction update - 1 Jan 2000

Otten Auke B C, Smeets Hubert J M

Abstract excerpt

BACKGROUND: The endosymbiosis of an alpha-proteobacterium and a eubacterium a billion years ago paved the way for multicellularity and enabled eukaryotes to flourish. The selective advantage for the host was the acquired ability to generate large amounts of intracellular hydrogen-dependent adenosine triphosphate. The price was increased reactive oxygen species (ROS) inside the eukaryotic cell, causing high...

Topics

Aging
Animals
Biological Evolution
DNA, Mitochondrial
Fertility
Fungi
Genome
Humans
Mutation
Phylogeny
Plants
Reproduction

Source

Open in PubMed

Identifiers

PMID: 25976758
DOI: 10.1093/humupd/dmv024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics