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Article

Evolutionary defined role of the mitochondrial DNA in fertility, disease and ageing.

Human reproduction update - 1 Jan 2000

Otten Auke B C, Smeets Hubert J M

Abstract excerpt

BACKGROUND: The endosymbiosis of an alpha-proteobacterium and a eubacterium a billion years ago paved the way for multicellularity and enabled eukaryotes to flourish. The selective advantage for the host was the acquired ability to generate large amounts of intracellular hydrogen-dependent adenosine triphosphate. The price was increased reactive oxygen species (ROS) inside the eukaryotic cell, causing high...

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PMID: 25976758
DOI: 10.1093/humupd/dmv024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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