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The paradox of cancer genes in non-malignant conditions: implications for precision medicine

17 Feb 2020

Abstract excerpt

Next-generation sequencing has enabled patient selection for targeted drugs, some of which have shown remarkable efficacy in cancers that have the cognate molecular signatures. Intriguingly, rapidly emerging data indicate that altered genes representing oncogenic drivers can also be found in sporadic non-malignant conditions, some of which have negligible and/or low potential for transformation to cancer. For...

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PMID: 32066498
DOI: 10.1186/s13073-020-0714-y

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