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Article

Synchronous Bilateral Tubal Serous Carcinomas in a Patient With Exon 13 Duplication and Loss of Function of BRCA1.

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists - 1 Mar 2018

Gurda Grzegorz T, Serdy Kate M, Yatsenko Svetlana A, Rajkovic Aleksandar, Carter Natalie J, Ahmed Rafay, Olawaiye Alexander B, Bhargava Rohit, Elishaev Esther

Abstract excerpt

We report the first case of distinct, synchronous serous carcinomas of the adnexa arising in a patient with a family history of breast and ovarian cancer and a germline loss of function mutation in BRCA1. Illustrating an exceedingly rare phenomenon of synchronous high-grade carcinomas with distinct histomorphologic, immunohistochemical and cytogenetic features, the case serves as a point of departure for the...

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Share to BRCA1 Protein
Share to Comparative Genomic Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystadenocarcinoma, Serous

Share to Gene Duplication

Share to Germ-Line Mutation

Share to Loss of Function Mutation

Share to Neoplasms, Multiple Primary

Share to Salpingo-oophorectomy

Source

Identifiers

PMID: 28463906
DOI: 10.1097/PGP.0000000000000392

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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