Allogeneic Transplantation in First Remission Improves Outcomes Irrespective of FLT3-ITD Allelic Ratio in FLT3-ITD-Positive Acute Myelogenous Leukemia.

doi:10.1016/j.bbmt.2016.03.027

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Article

Allogeneic Transplantation in First Remission Improves Outcomes Irrespective of FLT3-ITD Allelic Ratio in FLT3-ITD-Positive Acute Myelogenous Leukemia.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Jul 2016

Oran Betül, Cortes Jorge, Beitinjaneh Amer, Chen Hsiang-Chun, de Lima Marcos, Patel Keyur, Ravandi Farhad, Wang Xuemei, Brandt Mark, Andersson Borje S, Ciurea Stefan, Santos Fabio P, de Padua Silva Leandro, Shpall Elizabeth J, Champlin Richard E, Kantarjian Hagop, Borthakur Gautam

Abstract excerpt

The adverse prognosis of internal tandem duplication in the FMS-like tyrosine kinase 3 gene(s) (FLT3-ITD) in patients with acute myelogenous leukemia (AML) may depend on allelic burden. We compared postremission treatment with chemotherapy and hematopoietic stem cell transplantation (HSCT) in 169 FLT3-ITDmut intermediate cytogenetic risk AML patients with allelic ratio evaluable at diagnosis who achieved first...

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Identifiers

PMID: 27058617
DOI: 10.1016/j.bbmt.2016.03.027
PMCID: PMC6201699

Genes

FLT3
NPM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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