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Article

Proteolysis of HCF-1 by Ser/Thr glycosylation-incompetent O-GlcNAc transferase:UDP-GlcNAc complexes.

Genes & development - 15 Apr 2016

Kapuria Vaibhav, Röhrig Ute F, Bhuiyan Tanja, Borodkin Vladimir S, van Aalten Daan M F, Zoete Vincent, Herr Winship

Abstract excerpt

In complex with the cosubstrate UDP-N-acetylglucosamine (UDP-GlcNAc),O-linked-GlcNAc transferase (OGT) catalyzes Ser/ThrO-GlcNAcylation of many cellular proteins and proteolysis of the transcriptional coregulator HCF-1. Such a dual glycosyltransferase-protease activity, which occurs in the same active site, is unprecedented and integrates both reversible and irreversible forms of protein post-translational...

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Source

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Identifiers

PMID: 27056667
DOI: 10.1101/gad.275925.115
PMCID: PMC4840301

Genes

OGT
TPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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