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Article

O-GlcNAc transferase catalyzes site-specific proteolysis of HCF-1.

Cell - 4 Feb 2011

Capotosti Francesca, Guernier Sophie, Lammers Fabienne, Waridel Patrice, Cai Yong, Jin Jingji, Conaway Joan W, Conaway Ronald C, Herr Winship

Abstract excerpt

The human epigenetic cell-cycle regulator HCF-1 undergoes an unusual proteolytic maturation process resulting in stably associated HCF-1(N) and HCF-1(C) subunits that regulate different aspects of the cell cycle. Proteolysis occurs at six centrally located HCF-1(PRO)-repeat sequences and is important for activation of HCF-1(C)-subunit functions in M phase progression. We show here that the HCF-1(PRO) repeat is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21295698
DOI: 10.1016/j.cell.2010.12.030

Genes

OGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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