Article
The conserved threonine-rich region of the HCF-1PRO repeat activates promiscuous OGT:UDP-GlcNAc glycosylation and proteolysis activities.
The Journal of biological chemistry - 16 Nov 2018
Kapuria Vaibhav, Röhrig Ute F, Waridel Patrice, Lammers Fabienne, Borodkin Vladimir S, van Aalten Daan M F, Zoete Vincent, Herr Winship
Abstract excerpt
O-Linked GlcNAc transferase (OGT) possesses dual glycosyltransferase-protease activities. OGT thereby stably glycosylates serines and threonines of numerous proteins and, via a transient glutamate glycosylation, cleaves a single known substrate-the so-called HCF-1PRO repeat of the transcriptional co-regulator host-cell factor 1 (HCF-1). Here, we probed the relationship between these distinct glycosylation and...
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