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Article

Characterization of a Human Homologue of Proteolysis-Inducing Factor and Its Role in Cancer Cachexia

1 Sept 2004

Abstract excerpt

Cachexia is an important cause of secondary morbidity and mortality in patients with cancer. Previous studies have suggested that cancer-associated cachexia may be due in part to tumor-specific production and secretion of a glycosylated peptide, proteolysis-inducing factor, originally identified in a murine cancer cachexia model. We report here the cloning of a human cDNA that generates a peptide having...

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PMID: 15355918
DOI: 10.1158/1078-0432.ccr-04-0435

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