Article
On-chip microtubule gliding assay for parallel measurement of tau protein species.
Lab on a chip - 26 Apr 2016
Subramaniyan Parimalam Subhathirai, Tarhan Mehmet C, Karsten Stanislav L, Fujita Hiroyuki, Shintaku Hirofumi, Kotera Hidetoshi, Yokokawa Ryuji
Abstract excerpt
Tau protein is a well-established biomarker for a group of neurodegenerative diseases collectively called tauopathies. So far, clinically relevant detection of tau species in cerebrospinal fluid (CSF) cannot be achieved without immunological methods. Recently, it was shown that different tau isoforms including the ones carrying various types of mutations affect microtubule (MT)-kinesin binding and velocity in an...
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