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Article

Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity.

The Journal of biological chemistry - 27 May 2016

Anderson Kyle W, Mast Natalia, Hudgens Jeffrey W, Lin Joseph B, Turko Illarion V, Pikuleva Irina A

Abstract excerpt

Cytochrome P450 46A1 (CYP46A1) is a microsomal enzyme and cholesterol 24-hydroxylase that controls cholesterol elimination from the brain. This P450 is also a potential target for Alzheimer disease because it can be activated pharmacologically by some marketed drugs, as exemplified by efavirenz, the anti-HIV medication. Previously, we suggested that pharmaceuticals activate CYP46A1 allosterically through binding...

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Identifiers

PMID: 27056331
DOI: 10.1074/jbc.M116.723577
PMCID: PMC4882454

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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