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Article

In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds.

The Journal of biological chemistry - 4 Aug 2017

Mast Natalia, Anderson Kyle W, Johnson Kevin M, Phan Thanh T N, Guengerich F Peter, Pikuleva Irina A

Abstract excerpt

Cytochrome P450 46A1 (CYP46A1, cholesterol 24-hydroxylase) is the enzyme responsible for the majority of cholesterol elimination from the brain. Previously, we found that the anti-HIV drug efavirenz (EFV) can pharmacologically activate CYP46A1 in mice. Herein, we investigated whether CYP46A1 could also be activated by endogenous compounds, including major neurotransmitters. In vitro experiments with purified...

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Identifiers

PMID: 28642370
DOI: 10.1074/jbc.M117.794909
PMCID: PMC5546033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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