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Article

Molecular characterization of the hydroxylase HmtN at 1.3 Å resolution.

Biochemical and biophysical research communications - 27 Aug 2019

Zhang Huaidong, Chen Jie, Zhang Houjin

Abstract excerpt

Himastatin is a novel antibiotic with antitumor and antibacterial activity. In the himastatin biosynthesis pathway, HmtN is responsible for the hydroxylation of the piperazic acid (Pip) motif. Herein, we present the crystal structures of HmtN (1.3 Å), which is the first structure for a cytochrome P450 involved in the hydroxylation of cyclohexadepsipeptide during himastatin biosynthesis. Structure analysis...

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Identifiers

PMID: 28687492
DOI: 10.1016/j.bbrc.2017.07.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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