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Article

Procaspase-9 induces its cleavage by transnitrosylating XIAP via the Thioredoxin system during cerebral ischemia-reperfusion in rats.

Scientific reports - 7 Apr 2016

Zhang Dengyue, Zhao Ningjun, Ma Bin, Wang Yan, Zhang Gongliang, Yan Xianliang, Hu Shuqun, Xu Tie

Abstract excerpt

Transnitrosylation is an important mechanism by which nitric oxide (NO) modulates cell signaling pathways. For instance, SNO-caspase-3 can transnitrosylate the X-linked inhibitor of apoptosis (XIAP) to enhance apoptosis. XIAP is a potent antagonist of caspase apoptotic activity. Decrease in XIAP activity via nitrosylation results in SNO-XIAP-mediated caspase activation. Considering the functional liaison of...

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Source

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Identifiers

PMID: 27052476
DOI: 10.1038/srep24203
PMCID: PMC4823698

Genes

XIAP
TAT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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