Article
Impact of the Arg 16 allele of the B2AR gene on the effect of withdrawal of LABA in patients with moderate to severe asthma.
The Journal of asthma : official journal of the Association for the Care of Asthma - 1 Oct 2016
Slankard Marjorie, Michelis Mary Ann, Mansukhani Mahesh, McGoey Barbara, Paige Amy, Andrews Howard, Lederer David, Canfield Stephen, DiMango Emily
Abstract excerpt
INTRODUCTION: Long-acting beta agonists (LABAs) are effective for controlling asthma, however questions about their safety have led to concerns over use. Genetic polymorphisms at the 16 amino acid position of the beta-2 adrenergic receptor gene (B2AR) may be associated with increased risk. METHODS: A randomized, double blind study was conducted in patients with moderate to severe asthma being treated with...
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