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Article

Childhood asthma exacerbations and the Arg16 β2-receptor polymorphism: A meta-analysis stratified by treatment.

The Journal of allergy and clinical immunology - 1 Jul 2016

Turner Steve, Francis Ben, Vijverberg Susanne, Pino-Yanes Maria, Maitland-van der Zee Anke H, Basu Kaninika, Bignell Lauren, Mukhopadhyay Somnath, Tavendale Roger, Palmer Colin, Hawcutt Daniel, Pirmohamed Munir, Burchard Esteban G, Lipworth Brian

Abstract excerpt

BACKGROUND: The Gly-to-Arg substitution at the 16 position (rs1042713) in the β2-adrenoceptor gene (ADRB2) is associated with enhanced downregulation and uncoupling of β2-receptors. OBJECTIVES: We sought to undertake a meta-analysis to test the hypothesis that there is an interaction between the A allele of rs1042713 (Arg16 amino acid) and long-acting β-agonist (LABA) exposure for asthma exacerbations in...

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Identifiers

PMID: 26774659
DOI: 10.1016/j.jaci.2015.10.045
PMCID: PMC4931969

Genes

ADRB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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