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Article

Loss of salmeterol bronchoprotection against exercise in relation to ADRB2 Arg16Gly polymorphism and exhaled nitric oxide.

American journal of respiratory and critical care medicine - 15 Dec 2013

Bonini Matteo, Permaul Perdita, Kulkarni Tejaswini, Kazani Shamsah, Segal Alex, Sorkness Christine A, Wechsler Michael E, Israel Elliot

Abstract excerpt

RATIONALE: β2-Agonists are the treatment of choice for exercise-induced bronchoconstriction (EIB) and act through specific receptors (ADRB2). Arg16Gly polymorphisms have been shown to affect responses to regular use of β2-agonists. OBJECTIVES: To evaluate the influence of the Arg16Gly receptor polymorphism on salmeterol bronchoprotection in EIB and assess predictors of bronchoprotection. METHODS: A prospective,...

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Identifiers

PMID: 24228710
DOI: 10.1164/rccm.201307-1323OC
PMCID: PMC3917379

Genes

ADRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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