Article
The effects of a Gly16Arg ADRB2 polymorphism on responses to salmeterol or montelukast in Japanese patients with mild persistent asthma.
Pharmacogenetics and genomics - 1 May 2014
Konno Satoshi, Hizawa Nobuyuki, Makita Hironi, Shimizu Kaoruko, Sakamoto Tohru, Kokubu Fumio, Saito Takefumi, Endo Takeo, Ninomiya Hiroki, Iijima Hiroaki, Kaneko Norihiro, Ito Yoichi M, Nishimura Masaharu
Abstract excerpt
BACKGROUND: Long-acting β2-agonists and leukotriene receptor antagonists are two principal agents that can be added to inhaled corticosteroids (ICS) for patients with asthma that is not adequately controlled by ICS alone. The Gly16Arg genotype of the β2-adrenergic receptor (ADRB2) gene may influence the bronchodilator effects of β2-agonists. We hypothesized that differential responses to long-acting β2-agonists...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.