Article
ADRB2 Gly16Arg polymorphism, asthma control and lung function decline.
The European respiratory journal - 1 Nov 2011
Rebordosa C, Kogevinas M, Guerra S, Castro-Giner F, Jarvis D, Cazzoletti L, Pin I, Siroux V, Wjst M, Antò J M, de Marco R, Estivill X, Corsico A G, Nielsen R, Janson C
Abstract excerpt
Arg/Arg homozygotes for the Gly16Arg polymorphism in the β₂-adrenoreceptor gene (ADRB2) have a reduced response to short-acting β₂-agonists but no effect has been associated with long-acting β₂-agonists (LABAs). We selected 604 subjects with current asthma from the European Community Respiratory Health Study to evaluate whether asthma control and lung function decline were associated with Gly16Arg polymorphism,...
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