Article
beta-Adrenergic receptor polymorphisms and response to salmeterol.
American journal of respiratory and critical care medicine - 1 Mar 2006
Wechsler Michael E, Lehman Erik, Lazarus Stephen C, Lemanske Robert F, Boushey Homer A, Deykin Aaron, Fahy John V, Sorkness Christine A, Chinchilli Vernon M, Craig Timothy J, DiMango Emily, Kraft Monica, Leone Frank, Martin Richard J, Peters Stephen P, Szefler Stanley J, Liu Wenlei, Israel Elliot
Abstract excerpt
RATIONALE: Several studies suggest that patients with asthma who are homozygous for arginine at the 16th position of the beta2-adrenergic receptor may not benefit from short-acting beta-agonists. OBJECTIVES: We investigated whether such genotype-specific effects occur when patients are treated with long-acting beta-agonists and whether such effects are modified by concurrent inhaled corticosteroid (ICS) use....
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