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Extensive respiratory chain defects in inhibitory interneurones in patients with mitochondrial disease

18 Mar 2015

Abstract excerpt

AIMS: Mitochondrial disorders are among the most frequently inherited cause of neurological disease and arise due to mutations in mitochondrial or nuclear DNA. Currently, we do not understand the specific involvement of certain brain regions or selective neuronal vulnerability in mitochondrial disease. Recent studies suggest γ-aminobutyric acid (GABA)-ergic interneurones are particularly susceptible to...

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PMID: 25786813
DOI: 10.1111/nan.12238

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