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Article

Inhibition of BMI1 induces autophagy-mediated necroptosis

2 Apr 2016

Abstract excerpt

The clonal self-renewal property conferred by BMI1 is instrumental in maintenance of not only normal stem cells but also cancer-initiating cells from several different malignancies that represent a major challenge to chemotherapy. Realizing the immense pathological significance, PTC-209, a small molecule inhibitor of BMI1 transcription has recently been described. While targeting BMI1 in various systems...

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Identifiers

PMID: 27050456
DOI: 10.1080/15548627.2016.1147670

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