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Autophagy-mediated ID1 turnover dictates chemo-resistant fate in ovarian cancer stem cells

10 Aug 2024

Abstract excerpt

BACKGROUND: The mechanisms enabling dynamic shifts between drug-resistant and drug-sensitive states in cancer cells are still underexplored. This study investigated the role of targeted autophagic protein degradation in regulating ovarian cancer stem cell (CSC) fate decisions and chemo-resistance. METHODS: Autophagy levels were compared between CSC-enriched side population (SP) and non-SP cells (NSP) in multiple...

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PMID: 39123206
DOI: 10.1186/s13046-024-03147-z

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