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Article

A Modified Integrated Genetic Model for Risk Prediction in Younger Patients with Acute Myeloid Leukemia.

PloS one - 1 Jan 2016

Sloan Caroline E, Luskin Marlise R, Boccuti Anne M, Sehgal Alison R, Zhao Jianhua, Daber Robert D, Morrissette Jennifer J D, Luger Selina M, Bagg Adam, Gimotty Phyllis A, Carroll Martin

Abstract excerpt

BACKGROUND: Although cytogenetics-based prognostication systems are well described in acute myeloid leukemia (AML), overall survival (OS) remains highly variable within risk groups. An integrated genetic prognostic (IGP) model using cytogenetics plus mutations in nine genes was recently proposed for patients ≤60 years to improve classification. This model has not been validated in clinical practice. METHODS AND...

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Topics

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Share to Adolescent
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Models, Genetic

Share to Nucleophosmin

Share to Prognosis

Share to Risk Factors

Share to Young Adult

Source

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Identifiers

PMID: 27050425
DOI: 10.1371/journal.pone.0153016
PMCID: PMC4822876

Genes

FLT3
TET2
DNMT3A
IDH1
IDH2
ASXL1
NPM1
PHF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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