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Article

Loss of p53 induces tumorigenesis in p21-deficient mesenchymal stem cells.

Neoplasia (New York, N.Y.) - 1 Apr 2009

Rodriguez Rene, Rubio Ruth, Masip Manuel, Catalina Purificación, Nieto Ana, de la Cueva Teresa, Arriero Mar, San Martin Nuria, de la Cueva Ernesto, Balomenos Dimitrios, Menendez Pablo, García-Castro Javier

Abstract excerpt

There is growing evidence about the role of mesenchymal stem cells (MSCs) as cancer stem cells in many sarcomas. Nevertheless, little is still known about the cellular and molecular mechanisms underlying MSCs transformation. We aimed at investigating the role of p53 and p21, two important regulators of the cell cycle progression and apoptosis normally involved in protection against tumorigenesis. Mesenchymal stem...

Topics

Animals
Blotting, Western
Cell Transformation, Neoplastic
Cellular Senescence
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinase Inhibitor p21
Flow Cytometry
Mesenchymal Stem Cells
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Mutant Strains

Mutation

Neoplastic Stem Cells

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 19308294
DOI: 10.1593/neo.81620
PMCID: PMC2657886

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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