Article
Tumor suppressor gene alterations of spontaneously malignant transformed cells from human embryonic muscle in vitro.
Oncology reports - 1 Aug 2010
Wang Xianyao, Li Wenyu, Zheng Jiakun, Chen Qiang, Zou Haiying, Ma Lian, Lin Guangyu, Huang Tianhua, Huang Ge, Yang Liye
Abstract excerpt
Recent research has shown that mesenchymal stem cells (MSCs) which were cultured for long time could transform malignantly, the transformation mechanism is not clear yet, it might be associated with the activation of oncogenes and inactivation of tumor suppressor genes. In our initial investigation, we found that the cells arising from human embryonic muscle could spontaneously transform into malignancy in vitro...
Topics
- Animals
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Chromosome Aberrations
- Chromosomes, Human, Pair 9
- Cyclin-Dependent Kinase Inhibitor p15
- Embryo, Mammalian
- Fibrosarcoma
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Genes, p16
- Humans