Article

Identification of age-associated transcriptomic changes linked to immunotherapy response in primary melanoma

2022-01-25

Abstract excerpt

Melanoma is a lethal form of skin cancers that develops due to constitutive activation of MAPK signaling pathway driven by BRAF and NRAS mutations. Immunotherapeutic agents such as anti-PD-1 (pembrolizumab and nivolumab) and anti-CTLA-4 (ipilimumab) have revolutionized melanoma treatment, however drug resistance is rapidly acquired. Several studies reported the increase in melanoma rates in older patients. Thus, t...

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Literature Corpus work: 4383ff56-1b76-5c6a-af0d-5b692111f456
DOI: 10.1101/2022.01.23.22269554

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