Article

Unbiased preclinical phenotyping reveals neuroprotective properties of pioglitazone

2024-09-01

Abstract excerpt

<h4>ABSTRACT</h4> Animal models are essential for assessing the preclinical efficacy of candidate drugs, but animal data often fails to replicate in human clinical trials. This translational gulf is due in part to the use of models that do not accurately replicate human disease processes and phenotyping strategies that do not capture sensitive, disease-relevant measures. To address these challenges with the aim o...

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Literature Corpus work: 7441295b-5c6a-5e02-96e6-d0ac062b7053
DOI: 10.1101/2024.08.30.610328

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