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Article

Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation.

Atherosclerosis - 1 May 2016

da Silva Rafaela F, Lappalainen Jani, Lee-Rueckert Miriam, Kovanen Petri T

Abstract excerpt

BACKGROUND: In atherosclerotic lesions, cholesterol-laden macrophage foam cells are formed and exposed to M1- and M2-polarizing factors. However, the effects of the polarizing factors on the proinflammatory and the anti-inflammatory potential of foam cells are not known. OBJECTIVE: To investigate the effects of M1- and M2-polarizing factors on the expression of pro- and anti-inflammatory genes in cultured human...

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Source

Identifiers

PMID: 27038418
DOI: 10.1016/j.atherosclerosis.2016.03.012

Genes

CCL17
CCL19
CXCL8
MRC1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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