Article
miR-126 promotes M1 to M2 macrophage phenotype switching via VEGFA and KLF4.
PeerJ - 1 Jan 2023
Shou Xinyang, Wang Yimin, Jiang Qingyu, Chen Jun, Liu Qiang
Abstract excerpt
Background: Macrophage polarization and microRNA play crucial roles in the development of atherosclerosis (AS). The M1 macrophage phenotype contributes to the formation of plaques, while the M2 macrophage phenotype resolves inflammation and promotes tissue repair. MiR-126 has been found to play a role in regulating macrophage polarization in the context of AS. However, the exact mechanism of miR-126 requires...
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