Article
Inactivation of the spxA1 or spxA2 gene of Streptococcus mutans decreases virulence in the rat caries model.
Molecular oral microbiology - 1 Apr 2017
Galvão L C C, Rosalen P L, Rivera-Ramos I, Franco G C N, Kajfasz J K, Abranches J, Bueno-Silva B, Koo H, Lemos J A
Abstract excerpt
In oral biofilms, the major environmental challenges encountered by Streptococcus mutans are acid and oxidative stresses. Previously, we showed that the transcriptional regulators SpxA1 and SpxA2 are involved in general stress survival of S. mutans with SpxA1 playing a primary role in activation of antioxidant and detoxification strategies whereas SpxA2 serves as a back up activator of oxidative stress genes. We...
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