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Two Spx Regulators Modulate Stress Tolerance and Virulence in Streptococcus suis Serotype 2

29 Sept 2014

Abstract excerpt

Streptococcus suis serotype 2 is an important zoonotic pathogen causing severe infections in pigs and humans. The pathogenesis of S. suis 2 infections, however, is still poorly understood. Spx proteins are a group of global regulators involved in stress tolerance and virulence. In this study, we characterized two orthologs of the Spx regulator, SpxA1 and SpxA2 in S. suis 2. Two mutant strains (ΔspxA1 and ΔspxA2)...

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PMID: 25264876
DOI: 10.1371/journal.pone.0108197

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