Virulence of a spaP mutant of Streptococcus mutans in a gnotobiotic rat model.

doi:10.1128/IAI.67.3.1201-1206.1999

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Article

Virulence of a spaP mutant of Streptococcus mutans in a gnotobiotic rat model.

Infection and immunity - 1 Mar 1999

Crowley P J, Brady L J, Michalek S M, Bleiweis A S

Abstract excerpt

Streptococcus mutans, the principal etiologic agent of dental caries in humans, possesses a variety of virulence traits that enable it to establish itself in the oral cavity and initiate disease. A 185-kDa cell surface-localized protein known variously as antigen I/II, antigen B, PAc, and P1 has been postulated to be a virulence factor in S. mutans. We showed previously that P1 expression is necessary for in...

Topics

Animals
Bacterial Proteins
Germ-Free Life
Membrane Glycoproteins
Mutation
Rats
Rats, Inbred F344
Streptococcus mutans
Virulence

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Identifiers

PMID: 10024561
DOI: 10.1128/IAI.67.3.1201-1206.1999
PMCID: PMC96447

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