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Article

Two Spx proteins modulate stress tolerance, survival, and virulence in Streptococcus mutans.

Journal of bacteriology - 1 May 2010

Kajfasz Jessica K, Rivera-Ramos Isamar, Abranches Jacqueline, Martinez Alaina R, Rosalen Pedro L, Derr Adam M, Quivey Robert G, Lemos José A

Abstract excerpt

Previous work suggested that the underlying mechanisms by which the Streptococcus mutans ClpXP protease affects virulence traits are associated with accumulation of two orthologues of the Spx regulator, named SpxA and SpxB. Here, a thorough characterization of strains lacking the spx genes (Delta spxA, Delta spxB, and Delta spxA Delta spxB) revealed that Spx, indeed, participates in the regulation of processes...

Topics

Animals
Bacterial Proteins
Gene Expression Regulation, Bacterial
Hydrogen-Ion Concentration
Moths
Mutation
Oligonucleotide Array Sequence Analysis
Oxidative Stress
Polymerase Chain Reaction
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Sprague-Dawley

Streptococcus mutans

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 20233935
DOI: 10.1128/JB.00028-10
PMCID: PMC2863552

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