Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcription of Oxidative Stress Genes Is Directly Activated by SpxA1 and, to a Lesser Extent, by SpxA2 in Streptococcus mutans

20 Apr 2015

Abstract excerpt

UNLABELLED: The SpxA1 and SpxA2 (formerly SpxA and SpxB) transcriptional regulators of Streptococcus mutans are members of a highly conserved family of proteins found in Firmicutes, and they were previously shown to activate oxidative stress responses. In this study, we showed that SpxA1 exerts substantial positive regulatory influence over oxidative stress genes following exposure to H2O2, while SpxA2 appears to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Dental Protein Studies
Share to Oral microbiology and periodontitis research
Share to Streptococcal Infections and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25897032
DOI: 10.1128/jb.00118-15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcription of Oxidative Stress Genes Is Directly Activated by SpxA1 and, to a Lesser Extent, by SpxA2 in Streptococcus mutansPMID 25897032Read ↗

Inactivation of the spxA1 or spxA2 gene of Streptococcus mutans decreases virulence in the rat caries model.Semantic proximity Read ↗

Two Spx proteins modulate stress tolerance, survival, and virulence in Streptococcus mutans.Semantic proximity Read ↗

SpxA1 involved in hydrogen peroxide production, stress tolerance and endocarditis virulence in Streptococcus sanguinis.Semantic proximity Read ↗

SMU_1361c regulates the oxidative stress response of <i>Streptococcus mutans</i>Semantic proximity Read ↗

Identification of hydrogen peroxide production-related genes in Streptococcus sanguinis and their functional relationship with pyruvate oxidase.Semantic proximity Read ↗

SpxA1 and SpxA2 Function as a Stoichiometry-Dependent Regulatory Rheostat Governing Virulence Gene Expression in Group A StreptococcusSemantic proximity Read ↗

Two Spx Regulators Modulate Stress Tolerance and Virulence in Streptococcus suis Serotype 2Semantic proximity Read ↗

A novel aquaporin Aagp contributes to Streptococcus suis H 2 O 2 efflux and virulenceSemantic proximity Read ↗

Microarray analysis of macrophage response to infection with Streptococcus oralis reveals the immunosuppressive effect of hydrogen peroxide.Semantic proximity Read ↗

Increased Oxidative Stress Tolerance of a Spontaneously Occurring perR Gene Mutation in Streptococcus mutans UA159.Semantic proximity Read ↗

XRE family transcriptional regulator XtrSs modulates Streptococcus suis fitness under hydrogen peroxide stressSemantic proximity Read ↗

Pneumococcal Gene Complex Involved in Resistance to Extracellular Oxidative StressSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.