Article
Disruption of a Novel Iron Transport System Reverses Oxidative Stress Phenotypes of a dpr Mutant Strain of Streptococcus mutans.
Journal of bacteriology - 15 Jul 2018
Ganguly Tridib, Kajfasz Jessica K, Miller James H, Rabinowitz Eric, Galvão Lívia C C, Rosalen Pedro L, Abranches Jacqueline, Lemos José A
Abstract excerpt
The Dps-like peroxide resistance protein (Dpr) is essential for H2O2 stress tolerance and aerobic growth of the oral pathogen Streptococcus mutans Dpr accumulates during oxidative stress, protecting the cell by sequestering iron ions and thereby preventing the generation of toxic hydroxyl radicals that result from the interaction of iron with H2O2 Previously, we reported that the SpxA1 and SpxA2 regulators...
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