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Article

VE-statin/egfl7 regulates vascular elastogenesis by interacting with lysyl oxidases.

The EMBO journal - 18 Jun 2008

Lelièvre Etienne, Hinek Aleksander, Lupu Florea, Buquet Christelle, Soncin Fabrice, Mattot Virginie

Abstract excerpt

We previously characterized VE-statin/egfl7, a protein that is exclusively secreted by endothelial cells and modulates smooth muscle cell migration. Here, we show that VE-statin/egfl7 is the first known natural negative regulator of vascular elastogenesis. Transgenic mice, expressing VE-statin/egfl7 under the control of keratin-14 promoter, showed an accumulation of VE-statin/egfl7 in arterial walls where its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18497746
DOI: 10.1038/emboj.2008.103
PMCID: PMC2435125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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