Article
Lung development requires an active ERK/MAPK pathway in the lung mesenchyme.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jan 2017
Boucherat Olivier, Landry-Truchon Kim, Aoidi Rifdat, Houde Nicolas, Nadeau Valérie, Charron Jean, Jeannotte Lucie
Abstract excerpt
BACKGROUND: Reciprocal epithelial-mesenchymal communications are critical throughout lung development, dictating branching morphogenesis and cell specification. Numerous signaling molecules are involved in these interactions, but the way epithelial-mesenchymal crosstalk is coordinated remains unclear. The ERK/MAPK pathway transduces several important signals in lung formation. Epithelial inactivation of both Mek...
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