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Article

Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors.

Blood - 16 Jun 2016

Lavallée Vincent-Philippe, Krosl Jana, Lemieux Sébastien, Boucher Geneviève, Gendron Patrick, Pabst Caroline, Boivin Isabel, Marinier Anne, Guidos Cynthia J, Meloche Sylvain, Hébert Josée, Sauvageau Guy

Abstract excerpt

In this study, we analyzed RNA-sequencing data of 14 samples characterized by biallelic CEBPA (CEBPA(bi)) mutations included in the Leucegene collection of 415 primary acute myeloid leukemia (AML) specimens, and describe for the first time high frequency recurrent mutations in the granulocyte colony-stimulating factor receptor gene CSF3R, which signals through JAK-STAT proteins. Chemical interrogation of these...

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PMID: 27034432
DOI: 10.1182/blood-2016-03-705053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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