Article
Genetic lesions associated with chronic lymphocytic leukemia chemo-refractoriness.
Blood - 10 Apr 2014
Messina Monica, Del Giudice Ilaria, Khiabanian Hossein, Rossi Davide, Chiaretti Sabina, Rasi Silvia, Spina Valeria, Holmes Antony B, Marinelli Marilisa, Fabbri Giulia, Piciocchi Alfonso, Mauro Francesca R, Guarini Anna, Gaidano Gianluca, Dalla-Favera Riccardo, Pasqualucci Laura, Rabadan Raul, Foà Robin
Abstract excerpt
Fludarabine refractoriness (FR) represents an unsolved clinical problem of chronic lymphocytic leukemia (CLL) management. Although next-generation sequencing studies have led to the identification of a number of genes frequently mutated in FR-CLL, a comprehensive evaluation of the FR-CLL genome has not been reported. Toward this end, we studied 10 FR-CLLs by combining whole-exome sequencing and copy number...
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