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Article

Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease.

Neurobiology of disease - 1 Jan 2012

Franciosi Sonia, Ryu Jae K, Shim Yaein, Hill Austin, Connolly Colum, Hayden Michael R, McLarnon James G, Leavitt Blair R

Abstract excerpt

Central nervous system (CNS) inflammatory processes including microglial activation have been implicated in the pathogenesis of neurodegenerative diseases such as Huntington Disease (HD). We report age-dependent changes in striatal microglial morphology and vasculature in the YAC128 mouse model of HD. Decreases in microglial ramification along with a decrease in vessel diameter and increased vessel density and...

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PMID: 21946335
DOI: 10.1016/j.nbd.2011.09.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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