Article
Genome-wide association study identifies a new susceptibility locus for cleft lip with or without a cleft palate.
Nature communications - 16 Mar 2015
Sun Yimin, Huang Yongqing, Yin Aihua, Pan Yongchu, Wang Yirui, Wang Cheng, Du Yong, Wang Meilin, Lan Feifei, Hu Zhibin, Wang Guoqing, Jiang Min, Ma Junqing, Zhang Xiaozhuang, Ma Hongxia, Ma Jian, Zhang Weibing, Huang Qun, Zhou Zhongwei, Ma Lan, Li Yadi, Jiang Hongbing, Xie Lan, Jiang Yuyang, Shi Bing, Cheng Jing, Shen Hongbing, Wang Lin, Yang Yinxue
Abstract excerpt
Nonsyndromic cleft lip with or without a cleft palate (NSCL/P) is among the most common human congenital birth defects and imposes a substantial physical and financial burden on affected individuals. Here, we conduct a case-control-based GWAS followed by two rounds of replication; we include six independent cohorts from China to elucidate the genetic architecture of NSCL/P in Chinese populations. Using this...
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