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Article

Trimer Enhancement Mutation Effects on HIV-1 Matrix Protein Binding Activities.

Journal of virology - 15 Jun 2016

Alfadhli Ayna, Mack Andrew, Ritchie Christopher, Cylinder Isabel, Harper Logan, Tedbury Philip R, Freed Eric O, Barklis Eric

Abstract excerpt

UNLABELLED: The HIV-1 matrix (MA) protein is the amino-terminal domain of the HIV-1 precursor Gag (Pr55Gag) protein. MA binds to membranes and RNAs, helps transport Pr55Gag proteins to virus assembly sites at the plasma membranes of infected cells, and facilitates the incorporation of HIV-1 envelope (Env) proteins into virions by virtue of an interaction with the Env protein cytoplasmic tails (CTs). MA has been...

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Topics

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Share to env Gene Products, Human Immunodeficiency Virus
Share to gag Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Antigens

Share to Protein Interaction Domains and Motifs

Share to Protein Multimerization

Share to Virion

Share to Virus Replication

Source

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Identifiers

PMID: 27030269
DOI: 10.1128/JVI.00509-16
PMCID: PMC4886772

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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