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Article

HIV-1 matrix protein repositioning in nucleocapsid region fails to confer virus-like particle assembly.

Virology - 15 Aug 2008

Chang Ching-Yuan, Chang Yu-Fen, Wang Shiu-Mei, Tseng Ying-Tzu, Huang Kuo-Jung, Wang Chin-Tien

Abstract excerpt

The HIV-1 matrix (MA) protein is similar to nucleocapsid (NC) proteins in its propensity for self-interaction and association with RNA. Here we report on our finding that replacing MA with NC results in the production of wild type (wt)-level RNA and virus-like particles (VLPs). In contrast, constructs containing MA as a substitute for NC are markedly defective in VLP production and form virions with lower...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18550141
DOI: 10.1016/j.virol.2008.05.010
PMCID: PMC7103396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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