Article
Global rescue of defects in HIV-1 envelope glycoprotein incorporation: implications for matrix structure.
PLoS pathogens - 1 Jan 2013
Tedbury Philip R, Ablan Sherimay D, Freed Eric O
Abstract excerpt
The matrix (MA) domain of HIV-1 Gag plays key roles in membrane targeting of Gag, and envelope (Env) glycoprotein incorporation into virions. Although a trimeric MA structure has been available since 1996, evidence for functional MA trimers has been elusive. The mechanism of HIV-1 Env recruitment into virions likewise remains unclear. Here, we identify a point mutation in MA that rescues the Env incorporation...
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