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Article

Second site reversion of HIV-1 envelope protein baseplate mutations maps to the matrix protein.

Journal of virology - 20 Feb 2024

Alfadhli Ayna, Romanaggi CeAnn, Barklis Robin Lid, Barklis Eric

Abstract excerpt

The HIV-1 Envelope (Env) protein cytoplasmic tail (CT) recently has been shown to assemble an unusual trimeric baseplate structure that locates beneath Env ectodomain trimers. Mutations at linchpin residues that help organize the baseplate impair virus replication in restrictive T cell lines but not in permissive cell lines. We have identified and characterized a second site suppressor of these baseplate...

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Share to Antigens, Viral
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Share to env Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38193694
DOI: 10.1128/jvi.01742-23
PMCID: PMC10878238

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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