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Article

Characterization of replication defects induced by mutations in the basic domain and C-terminus of HIV-1 matrix.

Virology - 5 Dec 2007

Bhatia Ajay K, Campbell Nancy, Panganiban Antonito, Ratner Lee

Abstract excerpt

Extensive mutagenesis has defined distinct functional domains in the HIV-1 matrix domain (MA). In an attempt to more clearly define functions of regions of MA which affect viral entry, we analyzed mutations in the N-terminal basic and the C-terminal helical domains. Deletions of 8-10 amino acid residues of the C-terminal fifth helix of MA resulted in viruses that were only mildly defective in infectivity and...

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Share to env Gene Products, Human Immunodeficiency Virus
Share to gag Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17706261
DOI: 10.1016/j.virol.2007.06.046
PMCID: PMC2211416

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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