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Article

Species‐specific binding of human secretory component to SpsA protein of Streptococcus pneumoniae via a hexapeptide motif

1 May 2000

Abstract excerpt

SpsA, a pneumococcal surface protein belonging to the family of choline-binding proteins, interacts specifically with secretory immunglobulin A (SIgA) via the secretory component (SC). SIgA and free SC from mouse, rat, rabbit and guinea-pig failed to interact with SpsA indicating species-specific binding to human SIgA and SC. SpsA is the only pneumococcal receptor molecule for SIgA and SC as confirmed by complete...

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PMID: 10844660
DOI: 10.1046/j.1365-2958.2000.01897.x

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