Contribution of circulating Mfge8 to human T2DM and cardiovascular disease.

doi:10.1016/j.gene.2024.148712

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Article

Contribution of circulating Mfge8 to human T2DM and cardiovascular disease.

Gene - 15 Nov 2024

Rout Madhusmita, Malone-Perez Megan W, Park Gilseung, Lerner Megan, Kimble Frazer J, Apple Blair, Vaughn April, Payton Marvin, Stavrakis Stavros, Sidorov Evgeny, Fung KarMing A, Sanghera Dharambir K

Abstract excerpt

MFGE8 is a major exosome (EV) protein known to mediate inflammation and atherosclerosis in type 2 diabetes mellitus (T2DM) in animal studies. The pathophysiological role of this protein in obesity, T2DM, and cardiovascular disease is less investigated in humans. Earlier we reported a rare Asian Indian population-specific missense variant (rs371227978; Arg148His) in the MFGE8 gene associated with increased...

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Identifiers

PMID: 38901535
DOI: 10.1016/j.gene.2024.148712
PMCID: PMC11348863

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