Article
Asthma Genetics in the Post-GWAS Era.
Annals of the American Thoracic Society - 1 Mar 2016
Ober Carole
Abstract excerpt
Genome-wide association studies (GWAS) of asthma have yielded exciting results and identified novel risk alleles and loci. But, like other common complex diseases, asthma-associated alleles have small effect sizes and account for little of the prevalence of asthma. In this review, I discuss the limitations of GWAS approaches and the major challenges facing geneticists in the post-GWAS era and propose alternative...
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